A new paper from Jiayi Tang et al describes a free-breathing MRI-based liver fat quantification method that works equivalently across systems of different MRI manufacturers. This addresses two limitations of currently available MRI-based fat quantification methods, namely motion sensitivity, which requires breath holding and lowers feasibility in patients such as children and the infirm; and …
A new paper from Simchick et al. has demonstrated the feasibility of using perfused explanted human livers for validating a quantitative MRI-based technique which evaluates tissue microstructure and microvascular flow (i.e., intravoxel incoherent motion (IVIM) MRI). Explanted livers from deceased donors were connected to a perfusion system via the portal vein and hepatic artery, and MRI was performed under various highly controlled flow conditions. Using …
Prior work has shown that MRI-derived proton density fat fraction (PDFF) can diagnose metabolic dysfunction-associated steatotic liver disease (MASLD) noninvasively, but there is a paucity of data on the performance of PDFF to classify more advanced forms of the MASLD spectrum. In collaboration with the Liver Imaging Group at UCSD, patients undergoing weight loss surgery …
A new consensus paper based on literature review and an expert panel led by Dr. Scott Reeder reviews evidence for different MRI-based liver iron quantification methods with consensus recommendation for a confounder-corrected R2*-based approaches. Reeder SB, Yokoo T, França M, Hernando D, Alberich-Bayarri Á, Alústiza JM, Gandon Y, Henninger B, Hillenbrand C, Jhaveri K, Karçaaltıncaba …
Liver iron concentration (LIC) is directly correlated with total body iron. R2* MRI enabled accurate and reproducible quantification of liver iron overload over clinically relevant ranges of liver iron concentration (LIC). The data generated in this study provide the necessary calibrations for broad clinical dissemination of R2*-based LIC quantification. Hernando D, Zhao R, Yuan Q, …
A new guidelines paper from the ISMRM Quantitative MR Study group gives an overview and recommendations for the development, validation, qualification, and dissemination of quantitative MR methods. Led by Diego Hernando (past Chair of the ISMRM qMR Study Group), this paper frames the development of quantitative MR methods in terms of two central technical performance …
This study proposes a novel method for simultaneous T1w and T2w imaging using RF phase-modulated 3D gradient-echo imaging. T1-weighted and T2-weighted (T1w and T2w) imaging are essential sequences in routine clinical practice to detect and characterize a wide variety of pathologies. Many approaches have been proposed to obtain T1w and T2w contrast, although many challenges …
In this study of 145 student athletes with COVID-19 who had mild to moderate symptoms or no symptoms during acute infection, cardiac MRI findings (at a median of 15 days after a positive test result for COVID-19) were consistent with myocarditis in only 2 patients (1.4%), based on updated Lake Louise criteria. Thus, the utility …
Dr. Diego Hernando is lead author on a single site study correlating complex R2* mapping with liver iron concentration. Hernando D, Cook RJ, Qazi N, Longhurst CA, Diamond CA, Reeder SB. Complex confounder-corrected R2* mapping for liver iron quantification with MRI. Eur Radiol. 2020 Aug 12. doi: 10.1007/s00330-020-07123-x. Epub ahead of print. PMID: 32785766. Abstract …
Recent graduate Dr. Xiaoke Wang is the lead author on a paper detailing a novel method for encoding T2 in the phase signal of GRE methods. Wang X, Hernando D, Reeder SB. Phase-based T2 mapping with gradient echo imaging. Magn Reson Med. 2020 Aug;84(2):609-619. doi: 10.1002/mrm.28138. Epub 2019 Dec 24. PMID: 31872470; PMCID: PMC7180093. Abstract …