Phase-based T 2 mapping with gradient echo imaging

Purpose: Transverse relaxation time (T₂ ) mapping with MRI has a plethora of clinical and research applications. Current T₂ mapping techniques are based primarily on spin-echo (SE) relaxometry strategies that rely on the signal magnitude, and often suffer from lengthy acquisition times. In this work, we propose a phase-based T₂ mapping technique where T₂ information is encoded into the signal phase of rapid gradient echo (GRE) acquisitions.

Theory: Bloch equation simulations demonstrate that the phase of GRE acquisitions obtained with a very small inter-repetition RF phase increment has a strong monotonic dependence on T₂ , resulting from coherent transverse magnetization. This T₂ -dependent phase behavior forms the basis of the proposed T₂ mapping technique. To isolate T₂ -dependent phase from background phase, at least 2 data sets with different RF phase increments are acquired. The proposed method can also be combined with chemical shift encoded MRI to separate water and fat signals.

Methods: The feasibility of the proposed technique was validated in a phantom experiment. In vivo feasibility was demonstrated in the brain, knee, abdomen, and pelvis. Comparisons were made with SE-based T₂ mapping, spectroscopy, and T₂ values from the literature.

Results: The proposed method produced accurate T₂ maps compared with SE-based T₂ mapping in the phantom. Good qualitative agreement was observed in vivo between the proposed method and the reference. T₂ measured in various anatomies agreed well with values reported in the literature.

Conclusion: A phase-based T₂ mapping technique was developed and its feasibility demonstrated in phantoms and in vivo.