MR Phantoms

Emerging quantitative MRI methods are increasingly used for non-invasive diagnosis, staging and treatment monitoring in both clinical care and clinical trials. However, the lack of viable MRI phantoms that mimic the combination of water, fat, iron and fibrosis experienced in liver disease states is a major barrier to the development of new quantitative MRI biomarkers, as well as effective quality assurance in clinical environments. Such phantoms are also needed for quality assurance, calibration and qualification of MRI scanners for use in multicenter drug development trials. We work to develop and validate phantoms suitable for quantifying liver biomarkers, often performing multi-vendor MR studies with other institutions.

Phantom PDFF mapping demonstrates accurate fat quantification at all sites, vendors, field strengths and protocols. A) Representative PDFF map. B) Linear regression analysis showing high correlation, slope close to 1 and intercept close to 0 for all acquisitions. Hernando D, et al. 2017 Apr;77(4):1516-1524.

Selected Publications

  • Hernando D, Sharma S, Aliyari Ghasabeh M, Alvis B, Arora S, Hamilton G, Pan L, Shaffer J, Sofue K, Szeverenyi N, Welch E, Yuan Q, Bashir M, Kamel I, Rice M, Sirlin C, Yokoo T and Reeder S. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat–water phantom. Magnetic Resonance in Medicine. 2017 apr;77(4):1516-1524. DOI PMID
  • Sharma SD, Hernando D, Yokoo T, Bashir M, Shaffer J, Yuan Q, Ruschke R, Karampinos D, Brittain JH, Reeder SB, “Development and Multi-Center Validation of a Novel Water-Fat-Iron Phantom for Joint Fat and Iron Quantification,” In Proceedings of the 24th Annual Meeting of the International Society of Magnetic Resonance in Medicine, Singapore, 2016 (abstract 3274). Abstract and E-Poster
  • Wang X, Reeder S and Hernando D. An acetone-based phantom for quantitative diffusion MRI. Journal of Magnetic Resonance Imaging. 2017 apr;46(6):1683-1692. DOI PMID