Prior work has shown that MRI-derived proton density fat fraction (PDFF) can diagnose metabolic dysfunction-associated steatotic liver disease (MASLD) noninvasively, but there is a paucity of data on the performance of PDFF to classify more advanced forms of the MASLD spectrum. In collaboration with the Liver Imaging Group at UCSD, patients undergoing weight loss surgery were imaged with MRI to collect imaging biomarkers. PDFF was the most accurate single classifier for diagnosing MASLD, MASH, and fibrotic MASH. The most accurate multivariable classification models for MASLD, MASH, and fibrotic MASH included PDFF, demonstrating the central importance of PDFF for noninvasive assessment of the MASLD spectrum.
Panagiotopoulos N, Wolfson T, Harris DT, Batakis D, Agni R, Ceriani L, Covarrubias Y, Hamilton G, Middleton MS, Martins VF, Gamst AC, Oechtering TH, Sappenfield R, Horgan S, Grunvald E, Funk LM, Jacobsen GR, Lidor AO, Goodman JA, Khoury SB, Sirlin CB, Reeder SB. Proton density fat fraction for diagnosis of metabolic dysfunction-associated steatotic liver disease. Hepatology. 2025 Mar 25. doi: 10.1097/HEP.0000000000001318. Epub ahead of print. PMID: 40132140.
Read the full article at: https://doi.org/10.1097/hep.0000000000001318